Imipramine belongs to the group of tricyclic antidepressants and can be used to treat depressive states or chronic pain.

Imipramine belongs to a group of medicines called tricyclic antidepressants. Imipramine is mostly used in salt form as so-called imipramine hydrochloride.
Imipramine requires a prescription and may therefore only be taken as indicated by a doctor.


Imipramine is available as Dragées and also as Film-coated tablets available and these contain either 10 mg, 25 mg or 100 mg imipramine hydrochloride. The doctor decides which dosage should be selected individually for the patient.

application areas

Imipramine can be used for the following diseases or symptoms:

  • depressive illnesses
  • long-term pain management
  • Treatment of bed-wetting and night terrors


Not to be applied Imipramine is allowed in one of the following cases:

  • Hypersensitivity to any of the ingredients
  • acute alcohol poisoning
  • acute intoxication poisoning
  • acute pain medication poisoning
  • acute psychotropic intoxication
  • more acute Urinary retention
  • acute delirium
  • untreated increased pressure in the eye
  • Enlargement of the prostate
  • Narrowing of the gastric outlet
  • Intestinal paralysis
  • Treatment with other medicines for depression
  • Recovery period after one Heart attack

Only under strict medical supervision and control Imipramine may be used if the following information applies or applies to the patient:

  • severe liver damage
  • severe kidney damage
  • increased propensity for convulsions
  • Blood formation disorders
  • Adrenal market tumors
  • Previous damage to the heart

Imipramine in children

Imipramine should be used to treat children and adolescents under 18 years of age not applied as in studies in this age group no therapeutic benefit could be shown through this type of therapy.
Additionally come the serious possible side effects, such as on Cardiovascular system to weigh even heavier in children.
With regard to long-term use in children and adolescents in terms of growth, maturation, intellectual development and behavioral development, no data are available to date.
In children under 5 years of age, therapy with imipramine should not be given for indications for imipramine such as bedwetting and night terrors, as there is no empirical data.


Treatment with imipramine during pregnancy revealed so far no observation of teratogenic effects. Nevertheless, imipramine should be used especially in the first trimester of pregnancy only if there is a compelling medical indication be applied.
If use in the last trimester of pregnancy is unavoidable, the newborn should be monitored during the first month of life for the withdrawal symptoms of colic, cyanosis and agitation, which in newborns is difficult to distinguish from other causes shortly after birth.


If breast-feeding is used during treatment with imipramine, the child should be monitored for signs of imipramine effect and weaned at the first sign.

Use machines and ability to drive

Taking imipramine may reduce your ability to drive and operate heavy machinery. This applies in particular to the start of treatment, change of preparation, parallel medication with other drugs.

For this reason, we strongly advise against using electrical tools, machines and vehicles during this period!


The following interactions are known for imipramine:

  • enhanced effect of alcohol when taken at the same time
  • increased imipramine effect when taken at the same time Fluoxetine or fluvoxamine
  • enhanced effect of vasoconstricting agents when taken at the same time
  • severe side effects when taken at the same time other antidepressants (14 days break!)
  • Attenuation of Antihypertensive drugs when taken at the same time
  • enhanced effect of Antiarrhythmics when taken at the same time
  • increased imipramine effect when taken at the same time Neuroleptics
  • increased imipramine effect when taken at the same time Cimetidine
  • Reduced effectiveness of imipramine when taking Anti-epileptic drugs
  • Reduced effectiveness of imipramine Nicotine consumption
  • Reduced effectiveness of imipramine when taking the Birth control pills
  • Reinforcement of the effect anticoagulant drugs while taking imipramine

Imipramine and alcohol

During the treatment with imipramine absolutely no alcohol should be drunk!

Side effects

The following side effects have been observed with treatment with imipramine:

  • fatigue
  • sleepiness
  • Restlessness
  • sleep disorders
  • Dry mouth
  • dizziness
  • Hypotension (low blood pressure)
  • Tachycardias (too fast heartbeat)
  • Cardiac arrhythmias
  • Accommodation disorders (blurred vision)
  • Mydriasis (Dilated pupil)
  • Urinary retention
  • constipation