Side effects of prednisolone
The side effects of prednisolone result from the described effects, which influence:
- the hormone and electrolyte balance
- Nervous system
- Gastrointestinal tract
- immune system
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When prednisolone is administered, a possible side effect on the hormonal balance is the development of a Cushing's Syndrome with full moon face and trunk obesity.
Prednisolone therapy can also be seen under certain circumstances Disorders of the sodium and potassium balance, one Weight gain, an increase in blood lipids, a disorder of the sex hormone balance and the development of a Diabetes mellitus.
At the skin Various changes can result from prednisolone:
- Striae rubrae (stretch marks)
- Atrophy (parchment skin)
- Petechiae (Blood circulation in the skin)
- Steroid acne
- Pigmentation disorder.
The main side effects in muscles and skeleton include:
- Muscle weakness
- Muscle breakdown (atrophy
Regarding the nervous system, among other things depression, sleep disorders or psychosis occur.
Prednisolone side effects on the gastrointestinal tract show up as ulcers (ulcers), and bleeding Inflammation of the pancreas (Pancreatitis).
The circulatory system can be at increased risk for high blood pressure with prednisolone administration arteriosclerosis (Hardening of the arteries) and for Thrombosis exhibit.
The immune system is inhibited by prednisolone, so that latent infections break out or emerging infections are masked by the lack of immune reaction.
To the eyes occur among other things as a prednisolone side effect cataract (Cataract) or green Star (Glaucoma).
Prednisolone has had a wide variety of drug interactions. The result is either an increased or a weakened effect or side effect of the other drug.
Prednisolone increases the effectiveness of the following drugs:
- Cardiac glycosides (due to the potassium deficiency occurring with prednisolone administration)
- NSAIDs (more gastrointestinal bleeding), e.g. Diclofenac or ibuprofen
- certain muscle relaxants
- Atropine (increase in intraocular pressure)
- Ciclospoprin A (seizures)
The effectiveness of the following drugs is reduced:
- Antidiabetic drugs
With certain dehydrating agents (saluretics) and laxatives (laxatives) in combination with prednisolone, an increased excretion of potassium occurs.
Estrogens increase the effects of prednisolone, antacids, rifampicin, barbiturates and phenytoin decrease them.
Simultaneous administration of ACE inhibitors results in changes in the blood count.
Prednisolone should not be administered in case of hypersensitivity to this substance. Prednisolone is also contraindicated in certain malabsorption disorders (lactase deficiency, hereditary (hereditary) galactose intolerance, glucose-galactose malabsorption).
Caution should be exercised when prescribing prednisolone in a number of situations and illnesses, most of which can be seen in the unwanted side effects of Drug results.
These include active virus infections (Shingles, chickenpox, Herpes, poliomyelitis), by bacteria or systemic Fungal infection (Mycoses).
Also 8 weeks before or 2 weeks after a live vaccination (for example tetanus) or one that has already been passed tuberculosis one should use prednisolone cautiously, likewise with Gastrointestinal ulcers (Ulcers), difficult to treat high blood pressure, Heart failure (Heart failure) or Diabetes mellitus as well as heavier osteoporosis.
The patient also suffers cataracts (Cataract) or a mental illness, the administration of prednisolone should also be reconsidered.
If, on the other hand, there is one of the chronic inflammatory bowel diseases Ulcerative colitis or one Diverticulitis of the intestine (inflamed mucous membrane protuberances), the risk of a perforation of the intestine increases with prednisolone administration.
Lastly, prednisolone should be used in a pregnancy due to possibly increased malformation rates (Formation of clefts in the jaw and palate area) as well as in the Lactation can only be used cautiously.