Side effects of morphine
Dependence and development of tolerance
Opioids / morphine have great potential for dependence (side effects). These side effects are stronger or weaker depending on the type of ingestion and the substance being administered. The greatest potential for addiction, for example, has the intravenous supply of heroin (Derived from morphine), because Heorin floods the brain extremely quickly and thus gives the "desired" state of intoxication within a very short time after ingestion.
Withdrawal symptoms include sweating, pain, diarrhea (diarrhea), Vomit and circulatory failure.
The development of tolerance occurs when an opioid is taken for a long time. As a result, many of the effects are weakened, and habituation develops. Above all, it is the analgesic (actually the only desired) effect that wears off. Constipation is the least affected by tolerance development (constipation) and the Constriction of the pupil (Miosis), so they still occur without restriction even after prolonged intake of opioids.
Poisoning (opioid intoxication)
Overdose / side effects of Opioids is usually accompanied by a typical triad of symptoms:
- Miosis (narrow pupils)
- Respiratory depression
Therapeutic must be done as soon as possible Opioid antagonist given in order to neutralize the effect of the poison as best as possible. As such an antidote, naloxone is usually used. It is important to note that naloxone has a relatively short half-life of one hour, whereas most opioids work much longer in the body, so that naloxone must be injected at regular intervals.